Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70
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چکیده
منابع مشابه
Normotensive ischemic acute renal failure.
Copyright © 2007 Massachusetts Medical Society. A cute renal failure is defined as a rapid decrease in the glomerular filtration rate, occurring over a period of minutes to days. Because the rate of production of metabolic waste exceeds the rate of renal excretion in this circumstance, serum concentrations of markers of renal function, such as urea and creatinine, rise. The causes of acute rena...
متن کاملPreconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure.
Activation of hypoxia-inducible transcription factor (HIF) has been identified as an important mechanism of cellular adaptation to low oxygen. Normoxic degradation of HIF is mediated by oxygen-dependent hydroxylation of specific prolyl residues of the regulative alpha-subunits by HIF prolyl hydroxylases (PHD). It was hypothesized that inhibition of HIF degradation by either hypoxia or pharmacol...
متن کاملNephron heterogeneity in ischemic acute renal failure.
To uncover the reasons for reported internephron heterogeneity in acute renal failure (ARF) serial micropuncture experiments in norepinephrine-induced ARF and sham-infused control rats were carried out to investigate this phenomenon. Proximal tubular pressures (PT) were scattered at 24, 48, and 72 hr in ARF rats ranging from 4 to 42 mm Hg, but the majority were greater than the mean control val...
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Department of Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Queen Mary-University of London, Charterhouse Square, London EC1M 6BQ, UK Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy Department of Pathology, University of Aberdeen, Aberdeen, UK Department of Medicine and Therapeutics, University of...
متن کاملAcute Renal Failure Following Brake Fluid Poisoning
Brake fluid is a mixture of different Glycol derivatives which are poisoning and their ingestion triggers significant CNS symptoms, severe metabolic acidosis, cardiac, pulmonary, and renal failure. Here in this study, a case is reported who had been ingested 150mL of brake fluid for suicidal attempt.
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ژورنال
عنوان ژورنال: Kidney International
سال: 2005
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.2005.00326.x